Ghana's Anthony Annan believes mental preparation will be the key to success in next month's Group I clash in Sudan.
The two teams both boast 13 points in the group, but the Black Stars lead on goal difference.
"We have to work very hard before we can achieve something in Sudan, because it's going to be very difficult," the midfielder told BBC Sport.
"We have to be mentally prepared and put everything in place before we can beat them."
With the Confederation of African Football electing that teams sharing a similar a number of points go through on the head-to-head record, Ghana need just a draw in Sudan to qualify.
The two teams drew in Accra earlier in the campaign, but the Black Stars will emerge above the Sudanese on 07-09 October should they draw as they will lead overall on goal difference in the group.
"They have improved a lot because we now have the same points as them and only lead on goal difference," explained Annan, who is currently playing for Dutch side Vitesse Arnhem.
"It's going to be difficult in Sudan because the temperature and everything else is a little bit difficult.
"We have to approach this game very seriously - and we have to be on our form."
Source: BBC