Chelsea and Manchester United have been drawn to face each other in the quarter-finals of the Champions League, while Tottenham will play Real Madrid.
Barcelona meet Shakhtar Donetsk, with reigning champions Inter Milan drawn against Schalke.
Chelsea or United will go on to face either Inter or Schalke, while the winners of the other two last eight ties will meet in the other semi-final.
The quarter-final ties will be played on 5/6 and 12/13 April.
Chelsea have yet to win the Champions League and will have revenge on their minds after losing the 2008 Champions League final to United on penalties in Moscow.
The first leg between the Premier League rivals will take place at Stamford Bridge with United, who have won Europe's top competition three times, at home for the second leg.
Their tie means at least one English team is guaranteed a place in the semi-finals of the Champions League and the chance to make it to the final at Wembley on 28 May.
Spurs knocked out AC Milan in the last round and will travel to the Bernabeu for the first leg of their tie against Real Madrid before hosting the nine-time winners at White Hart Lane in the second leg.
Tottenham, who reached the European Cup semi-finals in 1962 when they lost to Benfica, will be out to stop Real manager Jose Mourinho's attempts to become the first man to win the Champions League with three different clubs.
Mourinho led Porto to glory in the competition in 2004 and guided Inter to victory last season before making the switch from the San Siro to Spain.
He has ended a run of Real Madrid failing to make it through to the last eight since 2004, with their last win in the Champions League coming in 2002.
Source: BBC