Hearts of Oak will play premiership side Berekum Arsenals in MTN FA Cup round of 32 tie at the Ohene Djan Stadium in Accra on 27 February.
Hearts lost 1-0 to the Gunners at the same venue in the first half of the league.
New coach Nobojsa Vucicevic will take charge of his first competitive match ahead of the commencement of the league on 2 March.
Rivals Asante Kotoko will host either Deportivo or Elmina Sharks at the Baba Yara Stadium on Sunday 27 February.
Medeama Sporting Club's encounter against Liberty Professionals at the Tarkwa T&T Park on 6 March.
Either Berekum Friction/B.A. Stars will face Berekum Chelsea at the Golden City Park next Sunday.