Asante Kotoko will be chasing a third straight win this season but face a difficult trip to Berekum Arsenals on Sunday in the Glo Premier League.
Interim head coach Johnson Smith is aiming at the four finish with the club currently placed seventh on the league table.
Kotoko are expecting striker Edward Affum to be ready after a medical at Tunisian side Etoile du Sahel and defender Prince Boateng also returning from a trial at Udinese.
Leaders AshantiGold have an easier to remain on top of the table at home to Great Olympics in Obuasi.
AshGold have three-points more than second-place Hearts of Oak which play bottom club Hasaacas at the Ohene Djan Stadium.
Third-place Aduana Stars travel to Kpando to face Heart of Lions; Liberty Professionals entertain All Stars at the Carl Reindorf Park.
Eleven Wise must beat Kessben FC to improve their relegation worries.
King Faisal host New Edubiase at the Baba Yara Stadium and Real Tamale United play Chelsea of Bechem in Tamale.