Miami opened the scoring in the 27 minutes of the game through Italian import Vincenzo Rannella.
San Fransisco were reduced to ten men as Pablo Dyego was shown a straight red card in the 40th minute to the dismay of the supporters and technical bench alike, which sparked flares on the touchline, with substitute midfielder Kyle Bekker also receiving his marching orders for dissent.
Rannella added his second of the night from the spot on the 50th minute mark.
Ghana forward Kwadwo Poku put the game beyond the San Francisco in the 56th minute before Tom Heinemann pulled one back for the host in the 71st minute.
The victory extended Alessandro Nesta side's lead at the top of the Spring season to 36 points, ten more than second placed side San Fransisco Delta.