Asante Kotoko face a tricky test against Liberty Professionals at the Baba Yara Stadium on Sunday.
Second-place Hearts of Oak play Bechem United in the late kick-off.
Other results:
Wa Stars 1-0 Aduana Stars
FT: Dwarfs 1-0 Medeama
Edubiase 4-2 Tema Youth
Wassaman 0-2 AshantiGold
Arsenal 1-0 Berekum Chelsea