Leaders Berekum Chelsea will have their hands full when they face a resurgent Asante Kotoko side at the Golden City Park on Sunday.
Chelsea, on top with a ten-point lead and unbeaten in six league matches, must find an antidote to stop Bogdan Korak's who are on the road to recovery.
Kotoko, like Chelsea, have won all two matches in the second half of the league.
Chelsea beat Asante Kotoko 2-3 at the Baba Yara Stadium in the corresponding fixture.
In Dormaa Ahenkro, champions Aduana Stars, third on the table, will be seeking to make amends against an erratic AshantiGold side, 8th-placed, side after going down 2-0 at Heart of Lions-their first heavy defeat in the league.
Seventh-placed Hearts of Oak must be Heart of Lions, in ninth, at the Ohene Djan Stadium to stabilize their form.
Second-bottom Real Tamale United must show enough fist for the battle at Medeama Sporting Club in Sekondi Stadium.
There is a relegation battle at the Coronation Park where bottom side B.A Stars host Liberty Professionals in second-bottom.
Ebusua Dwarfs suffered their first defeat in seven matches at Kotoko on Wednesday but have Wa All Stars at home to make amends.
Second-placed New Edubiase host Mighty Jets at the Gyemfi Park in Bekwai.