Inter Allies FC are hosting Liberty Professionals in a regional derby on Wednesday evening at the Cape Coast stadium instead of the Tema stadium due to a live TV broadcast schedule.
This will be the first ever meeting between the two sides on a neutral ground.
The "Eleven Is To One" side are poised to return to the winning ways and to make a quick revival from their slump last Sunday.
They were edged out by Asante Kotoko SC with a 1-0 loss at the Babayara stadium.
A win against Liberty Professionals on Wednesday will mean Inter Allies FC are winning their first two games in the league for the first time since joining in the 2013/2014 campaign.
Despite squandering three begging opportunities against the Porcupine Warriors on the weekend, Nsungusi Effiong Jnr. could earn his first start on Wednesday.
Kenichi Yatsuhashi has a fully strength squad available for selection against the Scientific Soccer Lads in the midweek.
After stumbling in their first match of the season, the Liberty Professionals head to Cape Coast to face regional rivals Inter Allies FC as they aim at making a rapid response.
The Scientific Soccer Lads put in a very disappointing performance last Sunday as they were beaten 3-1 at the Karl Reindorf by WAFA SC.
That was a baptism of fire for new trainer Reginald Asante Boateng who look to turns things around with at least a point on Wednesday from the derby.
With a game in hand, Liberty Professionals are the only side to pick a point in the premiership this campaign.
New signings Alex Ofosu Acheampong, Richard Yamoah and Adom-Abass Mustapha are expected to make their first appearances for the Scientific Soccer Lads if they are match fit and available for selection on Wednesday.
MATCH FACTS
Head To Head
Total league meetings = 8
Inter Allies FC wins = 4
Drawn matches = 1
Liberty Professionals wins = 3
~ Inter Allies FC have just one defeat in their last five fixtures in the premier league.
(W3 D1 L1)
~ Liberty Professionals have also lost just twice of their last six matches in the premier league.
(W4 D0 L2)
~ Inter Allies FC have recorded only one loss in their last thirteen home matches in the premier league.
(W10 D2 L1)
~ Liberty Professionals have managed to be victors twice in their last eight away games in the premiership.
(W2 D2 L4)
~ Inter Allies FC are undefeated in their four home encounters with Liberty Professionals in the premier league.
(W3 D1 L0)
~ Liberty Professionals have won three of their last six meetings with Inter Allies FC in the premiership.
(W3 D1 L2)
~ Inter Allies FC have conceded only two goals in their last eleven home fixtures in the premier league.
~ Liberty Professionals have conceded in each of their last five away matches in the premier league.
By Nuhu Adams