Hearts of Oak will welcome Karela United to the Accra Sports Stadium in match day 12 of the Special Competition on Wednesday.
The Phobians will be seeking to revenge that painful defeat at Ayinese on match day three.
Hearts lost the game by a lone goal after Solomon Sarfo Taylor's 42nd minute goal separated the two sides in a fiercely contested encounter.
Hearts currently sits on the summit of the table with 22 points after picking an important win against Dwarfs at the Cape Coast Stadium on Sunday.
Meanwhile, Karela United are having a good season in the competition as they are placed second on the league log with 21 points. They defeated WAFA by 2-0 on Sunday to move up the table. They have accrued 21 points after match day 11.
This will be a fiercely contested game between both sides with a lot at stake as the winner of this game will occupy top spot on the league log.
Two teams will qualify out of the group to the semi-finals stage.